Efficient Reprogramming of Diabetic Foot Ulcer Cells to Create Therapeutic Stem Cells

by Dr. Trupti Shirole on  August 13, 2016 at 5:42 PM Genetics & Stem Cells News
RSS Email Print This Page Comment bookmark
Font : A-A+

Induced pluripotent stem cells (iPSCs) have the potential to develop into a variety of cell types and can be used to create disease models to study new therapeutic approaches, such as activating regenerative capabilities that could convert non-healing fibroblasts into skin cells that regain their repair functions.
 Efficient Reprogramming of Diabetic Foot Ulcer Cells to Create Therapeutic Stem Cells
Efficient Reprogramming of Diabetic Foot Ulcer Cells to Create Therapeutic Stem Cells

Non-healing chronic wounds are a serious complication of diabetes. The potential to use a patient's own cells to treat non-healing chronic wounds took an important step forward as researchers successfully reprogrammed skin cells taken from diabetic foot ulcers to form induced pluripotent stem cells (iPSCs).

The reprogramming technique was similar in efficiency to the results achieved using healthy foot skin from non-diabetic patients, as described in the study published in Cellular Reprogramming, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

In the article "Generation of Induced Pluripotent Stem Cells From Diabetic Foot Ulcer Fibroblasts Using a Nonintegrative Sendai Virus", Behzad Gerami-Naini and coauthors from the School of Dental Medicine and the Sackler School of Graduate Biomedical Sciences, Tufts University (Boston, MA), and Beth Israel Deaconess Medical Center and the School of Engineering and Applied Sciences, Harvard University (Boston and Cambridge, MA), present a technique that uses a non-integrating Sendai virus to reprogram fibroblast cell lines. The researchers describe the future therapeutic potential of reprogrammed diabetic foot ulcer-derived cells, which could undergo epigenetic remodeling, a change that may reverse disease processes.

"This research has created two new approaches to the study and treatment of diabetic ulcers. It has revealed an important new source of cells for treatment of such ulcers," says Professor Sir Ian Wilmut, Editor-In-Chief of Cellular Reprogramming and Emeritus Professor in the MRC Centre for Regenerative Medicine, Scottish Center for Regenerative Medicine, University of Edinburgh (UK). "In addition, research on "reprogrammed cells" from such ulcers may reveal the molecular changes that caused the ulcers."

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Athletes Foot Stem Cells - Cord Blood Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Diabetes - Self-Monitoring of Blood Glucose (SMBG) Genetics and Stem Cells Diabetes and Exercise Pregnancy and Complications Glycemic Index Type 2 Diabetes 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive