Anabolic androgenic steroids (AAS) are synthetic derivatives of the naturally occurring male sex hormone testosterone. Use of AAS promotes the growth of skeletal muscle and the development of male sexual characteristics.
Long term exposure to elevated doses of Anabolic
Androgenic Steroids (AAS) can significantly affect aldosterone
concentration and serum sodium or potassium levels in albino mice, revealed investigations by researchers of Zoology Department of Cotton
College, Guwahati, and Gauhati University, Guwahati, Assam, India.
‘Long term exposure to elevated doses of Anabolic Androgenic Steroids (AAS) can significantly affect aldosterone concentration and serum sodium levels in albino mice.’
The research led by Dr. Rita Mahanta, Associate Professor (Retd.) in
the Department of Zoology, Cotton College, Guwahati and Ph.D. student,
Parmita Chowdhury from Gauhati University, Zoology Department, have
discovered that prolonged administration of Nandrolone Decanoate, an
AAS, upon a group of male albino mice significantly increased serum
aldosterone and sodium ion levels when compared with a group of albino
mice that did not receive such treatment. Post treatment alterations
were also revealed through measuring the level of potassium ion but this
change was reported to be insignificant.
This study, published in the journal Cardiovascular and Hematological Agents in Medicinal Chemistry
(Bentham Science), volume 14, issue 3, further emphasizes that a change
of this kind where a marked increase in aldosterone levels occurred
upon chronic exposure to Nandrolone Decanoate could be a possible
indication of steroid related cardiovascular disorders as several studies support the correlation between
aldosterone concentration and cardiovascular diseases.