E-cigarettes or electronic cigarettes are battery-operated devices designed to deliver nicotine with flavorings and other chemicals to users in vapor instead of smoke. Researchers at the University of California, San Diego School of Medicine and Veterans Affairs San Diego Healthcare System report data suggesting that e-cigarettes are toxic to human airway cells, suppress immune defenses and alter inflammation, while at the same time boosting bacterial virulence. The mouse study is published in the Journal of Molecular Medicine.
Senior author Laura E. Crotty Alexander, staff physician at the Veterans Affairs San Diego Healthcare System and assistant clinical professor at UC San Diego School of Medicine, said, "This study shows that e-cigarette vapor is not benign - at high doses it can directly kill lung cells, which is frightening. We already knew that inhaling heated chemicals, including the e-liquid ingredients nicotine and propylene glycol, couldn't possibly be good for you. This work confirms that inhalation of e-cigarette vapor daily leads to changes in the inflammatory milieu inside the airways."
‘E-cigarette vapor at high doses can directly kill lung cells. Daily inhalation of this vapor leads to changes in the inflammatory milieu inside the airways. At the same time it also boosts bacterial virulence.’
AdvertisementCrotty Alexander reported the preliminary results of this work at the American Thoracic Society annual meetings in 2014 and 2015. But now her team has also seen their findings hold up in mice. Inflammatory markers - signs of full-body inflammation - in the airways and blood of mice that inhaled e-cigarette vapors for one hour a day, five days a week, for four weeks were elevated by 10% compared to unexposed mice.
Crotty Alexander said, "We don't know specifically which lung and systemic diseases will be caused by the inflammatory changes induced by e-cigarette vapor inhalation, but based on clinical reports of acute toxicities and what we have found in the lab, we believe that they will cause disease in the end. Some of the changes we have found in mice are also found in the airways and blood of conventional cigarette smokers, while others are found in humans with cancer or inflammatory lung diseases."
Conversely, bacterial pathogens exposed to e-cigarette vapor benefited. Specifically, Staphylococcus aureus bacteria were better able to form biofilms, adhere to and invade airway cells and resist human antimicrobial peptides after exposure to e-cigarette vapor.
E-cigarette vapor extract-exposed bacteria were also more virulent in a mouse model of pneumonia. All mice infected with normal methicillin-resistant S. aureus (MRSA), an antibiotic-resistant 'superbug', survived. Meanwhile, 25% of mice infected with MRSA pre-exposed to e-cigarette vapor died.
The results were consistent with e-liquids from seven different manufacturers, demonstrating that the findings are not limited to one formula or brand.
Crotty Alexander and team also recently reported that MRSA bacteria exposed to conventional cigarette smoke are more resistant to killing by the immune system than unexposed bacteria.
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