Brain cells that multiply to help birds sing during breeding season are known to die back naturally later in the year.
For the first time researchers have described the series of events that cues new neuron growth each spring, and it all appears to start with a signal from the expiring cells the previous fall that primes the brain to start producing stem cells. If scientists can further tap into the process and understand how those signals work, it might lead to ways to exploit these signals and encourage replacement of cells in human brains that have lost neurons naturally because of aging, severe depression or Alzheimer's disease, said Tracy Larson, a University of Washington doctoral student in biology.
AdvertisementShe's lead author of a paper in the Sept. 23 Journal of Neuroscience on brain cell birth that follows natural brain cell death.Neuroscientists have long known that new neurons are generated in the adult brains of many animals, but the birth of new neurons - or neurogenesis - appears to be limited in mammals and humans, especially where new neurons are generated after there's been a blow to the head, stroke or some other physical loss of brain cells, Larson said.
That process, referred to as "regenerative" neurogenesis, has been studied in mammals since the 1990s.This is the first published study to examine the brain's ability to replace cells that have been lost naturally, Larson said. "Many neurodegenerative disorders are not injury-induced," the co-authors write, "so it is critical to determine if and how reactive neurogenesis occurs under non-injury-induced neurodegenerative conditions." The researchers worked with Gambel's white-crowned sparrows, a medium-sized species 7 inches (18 centimeters) long that breeds in Alaska, then winters in California and Mexico. Sometimes in flocks of more than 100 birds, they can be so plentiful in parts of California that they are considered pests. The ones in this work came from Eastern Washington.
Like most songbirds, Gambel's white-crowned sparrows experience growth in the area of the brain that controls song output during the breeding season when a superior song helps them attract mates and define their territories. At the end of the season, probably because having extra cells exacts a toll in terms of energy and steroids they require, the cells begin dying naturally and the bird's song degrades.
Gambel's white-crowned sparrows are particularly good to work with because their breeding cycle is closely tied to the amount of sunlight they receive. Give them 20 hours of light in the lab, along with the right increase of steroids, and they are ready to breed. Cut the light to eight to 12 hours and taper the steroids, the breeding behavior ends.