Drug Used for DNA Repair Defects Could Treat Leukemia and Other Cancers: Study

by Bidita Debnath on  August 28, 2014 at 12:03 AM Research News
RSS Email Print This Page Comment
Font : A-A+

A team of scientists have found that a drug originally designed for killing a limited type of cancer cells with DNA repair defects could potentially be used to treat leukaemia and other cancers.
 Drug Used for DNA Repair Defects Could Treat Leukemia and Other Cancers: Study
Drug Used for DNA Repair Defects Could Treat Leukemia and Other Cancers: Study

The study was led by Research Associate Professor Motomi Osato and Professor Yoshiaki Ito from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS).

The new study suggests that treatment with poly (ADP-ribose) polymerase (PARP) inhibitors, together with standard chemotherapy drugs, could be more effective in combating leukaemia. In the same study, researchers found that the inactivation of RUNX genes causes DNA repair defects and promotes the development of leukaemia and other cancers. The study was first published online in the leading journal Cell Reports last month.

Unlike other cancers which are more commonly seen in the elderly, leukaemia is notorious for its high prevalence among young people. There has been little advancement in the treatment of leukaemia. Chemotherapy with or without hematopoietic stem cell transplantation remains the current standard of care, resulting in a cure rate of around 50 per cent. The RUNX family genes are among the most frequently inactivated genes in leukaemia and other cancers. According to previous studies, RUNX1 is one of the most frequently mutated genes in leukaemia and RUNX3 is associated with the development of the disease.

Source: Eurekalert

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions
drraja Thursday, August 28, 2014

Good news to the mankind and if the anti cancer drugs were made available at an affordable cost to the patients it will be the highlight .

Related Links

More News on:

DNA Finger Printing Drug Toxicity Leukemia Chronic Myeloid Leukemia Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Signature Drug Toxicity Multiple Myeloma Epigenetics Bone Marrow Transplantation 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive