We might have heard many saying that they take multivitamins to prevent or delay the onset of heart disease and some even say that it's because they don't eat healthy and so they make it up with the pills.
A 11-year follow up points out that there was no significant difference in risk of major cardiovascular disease (CVD) events among men who took a multivitamin compared to those that took a placebo.
‘Foods, nutrients, dietary patterns or supplement use assessed before the start of the clinical trial and no measurable influence on the effectiveness of a multivitamin on CVD risk in middle-aged and older men.’
The new study published in JAMA Cardiology examined whether multivitamins might help prevent CVD events among those in the PHS II with less nutritious diets. The Physicians' Health Study II (PHS II) remains the only randomized, large-scale, long-term trial to test whether a daily multivitamin reduced cardiovascular disease risk.
The PHS II includes more than 14,000 US male physicians over 50 years of age who have completed comprehensive food frequency questionnaires. By studying this population over time in a randomized clinical trial, the research team was able to eliminate many confounding variables.
The team also had the opportunity to evaluate a wide range of dietary factors, including intake of fruits and vegetables, whole grains, nuts, dairy products, and red and processed meats, along with key nutrients such as vitamin B6, vitamin B12, vitamin D, and others.
Overall, the investigators found that foods, nutrients, dietary patterns or supplement use assessed before the start of the clinical trial and no measurable influence on the effectiveness of a multivitamin on CVD risk in middle-aged and older men.
"Intuitively, many had thought that men with 'poor' nutritional status at baseline may benefit more from long-term multivitamin use on cardiovascular outcomes; however, we did not see any evidence for this in our recent analysis," said corresponding author Howard Sesso, ScD, MPH, of the Division of Preventive Medicine and the Division of Aging at BWH.
"Given the continued high prevalence of multivitamin use in the US, it remains critical for us to understand its role on nutritional status and other long-term health outcomes through clinical trials such as PHS II and other new research initiatives."