Discovery of Pain Gene Paves Way for Treating Congenital Insensitivity

by Reshma Anand on  December 7, 2015 at 3:16 PM Research News   - G J E 4
Humans can easily feel pain during an injury, but some people can't feel the same due to some malfunctioning in genes. When these genes are altered, the insensitivity disappears.
Discovery of Pain Gene Paves Way for Treating Congenital Insensitivity
Discovery of Pain Gene Paves Way for Treating Congenital Insensitivity

In a new study published in the Journal Nature Communications Researchers from the University of London have identified that mutations in SCN9A gene encoding voltage-gated sodium channel Nav1.7 causes congenital insensitivity in some people.

‘Mutations in SCN9A gene causes congenital insensitivity by producing opioid proteins in higher amounts. A drug called naloxone reduces these opioids and brings back sensitivity in people suffering with this disorder. ’
The Nav1.7 channel is responsible for transporting pain signals in both humans and mice. Researchers analyzed transgenic mice or knockout mice, mice devoid of this SCN9A gene. They found that these mice that lacked the gene produced opioid proteins in higher amounts which in turn suppressed their ability to feel pain.

Therefore, they induced an opioid blocker called Naloxone into the mice which reduced the production of opioid proteins in their body. The mice were able to feel pain due to the reduction of these proteins, which the researchers concerned as an effective treatment for people suffering with congenital insensitivity.

They also tried this drug naloxone on a 37-year-old woman suffering with this disorder. On treatment with this drug, the woman devoid of this SCN9A gene was able to feel the pain again. But the treatment imposes some side effects and may not be considered as an effective treatment for congenital insensitivity.

"Opioids and Nav1.7 blockers could provide much stronger analgesics, but they will not necessarily be better for patients. If we take the combination therapy route, people would have to take opioids throughout the lifetime, which is not a welcome thing," said John Wood of University College London.

Reference: Minett, M. S. et al. Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7. Nat. Commun. 6:8967 doi: 10.1038/ncomms9967 (2015).

Source: Medindia

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