Diabetic Kidney Disease Prevented for the First Time

by Shirley Johanna on  February 11, 2017 at 11:51 PM Diabetes News
RSS Email Print This Page Comment bookmark
Font : A-A+

The progression of Diabetic Kidney Disease (DKD) has been successfully prevented for the first time by an Australian pharmaceutical company. DKD is an often fatal long-term complication of type 2 diabetes which is the most common cause of severe renal disease. It affects one-third of people with type 2 diabetes and has no viable treatment until now.
Diabetic Kidney Disease Prevented for the First Time
Diabetic Kidney Disease Prevented for the First Time

An international team of scientists in collaboration with Melbourne-based global biotechnology leader CSL Limited investigated a therapeutic approach that targets the transport of fatty acids, or lipids, from the blood into tissues to treat DKD.

Using 2H10, an antibody developed by CSL, the researchers were able to block Vascular Endothelial Growth Factor B (VEGF-B), a protein that affects the transport of lipids into body tissue. Elevated levels of VEGF-B are a common symptom among patients with DKD.

By inhibiting VEGF-B signalling the researchers were able to reduce the accumulation of lipid deposits within the kidney and moderate the progression of kidney disease in a number of models of type 1 and 2 diabetes.

"This research addresses an important area of unmet medical need and could lead to an entirely new approach to the treatment of type 2 diabetes," Andrew Nash, Senior Vice President of Research at CSL, said in a statement on Friday.

Professor Ulf Eriksson, the lead researcher on the study, said that "the study reveals some mechanistic understanding of the disease progression and challenges the hypothesis that diabetic kidney disease is simply the result of chronic elevated blood glucose."

The study, which was published in respected journal Cell Metabolism on Friday, was carried out on mice but a human trial of the protein in humans with DKD has been flagged for the near future.



Source: IANS

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

left kidney appears bulky and shows perinephric fat strending left kidney measures 110*62 mm, there is fullness or left pelvicalyceal system. left ureter is also mildley dilated with mild wall thicking and mild periureteric fat strending and i m diabitic patient this prob i take 1 tablet every night niftran cp 100 mg how i get early recovery for this prob plz sujjest me thnx for ur support sir.

Related Links

More News on:

Diabetes - Self-Monitoring of Blood Glucose (SMBG) Diabetes and Exercise Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Kidney Disease Kidney Pregnancy and Complications Glycemic Index Type 2 Diabetes 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive

Loading...