Researchers said Monday that managing type 2 diabetes in overweight people is most effective with stomach-shrinking surgeries than trying to shed weight with pills and lifestyle changes.
Three years into a study that compares the various approaches -- medical therapy, gastric bypass and sleeve gastrectomy -- the findings show that the two procedures are still superior at reducing glycemic levels and weight.
AdvertisementThe latest results from the largest randomized controlled trial of its kind were published in the New England Journal of Medicine and discussed at the American College of Cardiology annual meeting.
"Both surgical options maintain their supremacy over standard intensive medical therapy at the three-year mark," said lead investigator Philip Schauer, director of the Bariatric and Metabolic Institute at the Cleveland Clinic.
"There is this notion that if we keep adding medications and pushing patients to lose weight on their own, they will eventually achieve the same type of results as those undergoing surgery, but that wasn't the case here."
The research includes 150 people, who were aged 41 to 57 when they began the study. They were all overweight or obese, with uncontrolled diabetes that had persisted for at least eight years. Each was taking at least three diabetes medications.
At the start of the trial, patients had an average blood glucose level of 9.2 percent.
The goal of achieving glycemic control was defined as a three-month average blood glucose level of six percent or lower.
That target is slightly more aggressive than the American Diabetes Association recommendation of seven percent.
After three years, just five percent of patients who did not have surgery but attempted to lose weight through counseling sessions, diet and medication had achieved the desired level of glycemic control.
The surgery groups did much better, with 37.5 percent of gastric bypass and 24.5 percent of sleeve gastrectomy patients meeting the mark.
Gastric bypass involves reducing the stomach to below three percent of its natural volume, then connecting a new gastric pouch that bypasses the stomach and goes straight to the intestine.
In sleeve gastrectomy, part of the patient's stomach is removed to reduce its volume by about 75 percent.
Weight loss after three years was also five to six times greater in patients who had one of the surgeries.
The gastric bypass group lost on average 24 percent of their body weight while the sleeve gastrectomy patients shed 21 percent. Those on medical therapy alone lost four percent.
Surgical patients also did better on measures of body mass index, weight control, and cholesterol levels.
Some 23 million American adults have type 2 diabetes, and most of them are overweight or obese.
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