Effects of Dapagliflozin in Chronic Kidney Disease
In this latest analysis, Phil McEwan, PhD (Health Economics and Outcomes Research Ltd., Cardiff, UK) and his colleagues estimated the cost-effectiveness of dapagliflozin added to standard therapy, compared with standard therapy alone, based on the results of the DAPA-CKD trial and considered from a multinational European healthcare system perspective.
Prevention of Kidney Disease - Causes & Prevention
Kidney damage is usually detected at advanced stages. Healthy lifestyle, keeping diabetes and blood pressure under check, and regular tests can help prevent it.
Kidney damage is usually detected at advanced stages. Healthy lifestyle, keeping diabetes and blood pressure under check, and regular tests can help prevent it.
‘Dapagliflozin, an anti-diabetic drug was shown to be an efficacious treatment for CKD in the Dapagliflozin And Prevention of Adverse outcomes in CKD (DAPA-CKD) trial.’
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Treatment with dapagliflozin was predicted to slow the progression of CKD to kidney failure, to reduce the incidence of adverse clinical outcomes including hospitalization for heart failure, and to increase life expectancy by 1.7 years. Delayed CKD progression to kidney failure and reduced incidence of hospitalization for heart failure provided important cost-offsets to the drug acquisition cost of dapagliflozin. “Our results indicate that should patients with chronic kidney disease be treated with dapagliflozin at an early stage of disease, the rate of cardio-renal complications could be reduced leading to improved health-related quality of life in patients and significant benefits for healthcare systems in a cost-effective manner,” said Dr. McEwan.
An accompanying editorial notes that the study adds to a plethora of work demonstrating the cost-effectiveness of sodium-glucose cotransporter-2 inhibitors in both diabetic and non-diabetic kidney disease.
Quiz on Kidney
The kidneys are two bean-shaped organs, each about the size of a fist, and are located just below the rib cage, one on each side of your spine.
Healthy kidneys filter about half a cup of blood every minute, removing wastes and extra water to make urine. The urine flows from the kidneys to the bladder through two thin tubes of muscle called ureters, one on each side of your bladder. The bladder stores urine. The kidneys, ureters, and bladder are partof the urinary tract.
Without this balance, nerves, muscles, and other tissues in the body may not work normally.
The kidneys are two bean-shaped organs, each about the size of a fist, and are located just below the rib cage, one on each side of your spine.
Healthy kidneys filter about half a cup of blood every minute, removing wastes and extra water to make urine. The urine flows from the kidneys to the bladder through two thin tubes of muscle called ureters, one on each side of your bladder. The bladder stores urine. The kidneys, ureters, and bladder are partof the urinary tract.
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Without this balance, nerves, muscles, and other tissues in the body may not work normally.
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- Control your blood pressure
- Make red blood cells
- Keep your bones strong and healthy
Animation On Key Hole Surgery for Kidney Stone Removal or Percutaneous Nephrolithotomy (PCNL)
Graphical explanation of stone removal from the kidney with a minimally invasive procedure called Percutaneous Nephrolithotomy. This is a major endoscopic procedure needing hospitalization.
Graphical explanation of stone removal from the kidney with a minimally invasive procedure called Percutaneous Nephrolithotomy. This is a major endoscopic procedure needing hospitalization.
Top 10 Alarming Facts on Kidney Disease
The incidence of kidney failure (or chronic kidney disease) has doubled over the last 15 years. Here are some alarming facts on kidney disease.
The incidence of kidney failure (or chronic kidney disease) has doubled over the last 15 years. Here are some alarming facts on kidney disease.
