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Development Of HIV-1 Vaccine

by Rukmani Krishna on  November 15, 2012 at 11:39 PM AIDS/HIV News   - G J E 4
HIV-1 is a genetically diverse collection of viruses. This makes it a moving target in vaccine development.
 Development Of HIV-1 Vaccine
Development Of HIV-1 Vaccine
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In a study published in the Journal of Clinical Investigation, researchers led by Brad Jones at the University of Toronto in investigated the feasibility of eliminating HIV-infected cells by targeting cellular immune responses against a human endogenous retrovirus (HERV). HERVs are the DNA remnants of ancient infectious retroviruses that became part of the germ line cells of our ancestors.

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Jones and colleagues found that HIV infection stimulated the expression of HERV proteins, effectively tagging HIV-infected cells. Immune cells targeted to these proteins specifically eliminated cells infected with several different strains of HIV in vitro. This study suggests that HERV-targeted immune responses should be considered in the development of HIV vaccines.TITLE:
HERV-K-targeted T-cells eliminate diverse HIV-1/2 and SIV primary isolatesAUTHOR CONTACT:
Brad Jones
University of Toronto, Toronto, ON, CAN
Phone: 617-777-9151; E-mail: bjones.ut@gmail.com

Source: Eurekalert
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