X

Dental Pulp Stem Cells Promote Regeneration of Retinal Cells After Injury: Study

by Bidita Debnath on  July 08, 2014 at 9:40 PM Research News   - G J E 4
A -A +
Researchers have discovered that stem cells isolated from the teeth, termed dental pulp stem cells (DPSC), can protect retinal ganglion cells (RGCs) from death following injury and promote regeneration of their axons along the optic nerve.
 Dental Pulp Stem Cells Promote Regeneration of Retinal Cells After Injury: Study
Dental Pulp Stem Cells Promote Regeneration of Retinal Cells After Injury: Study

The study was led by Dr. Ben Scheven, Dr. Wendy Leadbeater and Ben Mead at the University of Birmingham, UK. RGC loss is the leading cause of blindness and can arise through traumatic injury or degenerative diseases such as glaucoma.

Neurotrophic factors (NTFs), which travel along the axon of a neuron to a cell body act as survival signals however, following injury or disease, this supply is lost and RGCs die. Supplementation of injured RGC with an alternative source of NTFs is paramount to protecting them from death.

The study, reported on Neural Regeneration Research (Vol. 9, No. 6, 2014), confirmed that DPSCs naturally express multiple NTFs which can supplement the lost supply of NTF and protect RGCs from death as well as promote regeneration of their axons.

"Cell therapy is a promising treatment option as it provides a potentially limitless source of multiple growth factors for injured neurons", stressed first author Ben Mead. He also said "For clinical application, comparisons with other stem cells as well as development of safe delivery mechanisms are to be investigated in the future".

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

Most Popular News on Medindia

P
M
X

Ask an Expert

Ask an Expert+
s
Visualization of Peripheral Nerve Regeneration Pr...
 Visualization of Peripheral Nerve Regeneration Process
S  Houshiheisan Maintains Stabilization of Neurovascular Units
Houshiheisan Maintains Stabilization of Neurovasc...