Discovery of a New RNA Letter That Regulates Gene Expression
RNA, considered the DNA template for protein translation, often appears with an extra letter, and this letter is the regulatory key for control of gene expression.
RNA, considered the DNA template for protein translation, often appears with an extra letter, and this letter is the regulatory key for control of gene expression.
‘As the OMics Compendia Commons (OMiCC) user community grows, the platform will develop into a rich resource that can transform the increasing amounts of public data into novel biological insights.’
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Public databases contain millions of gene expression profiles--data that describe the degree to which genes are turned on or off under certain conditions. Potentially, scientists could reuse these data to generate and address new research questions. For example, researchers could re-purpose a dataset comparing blood samples from drug-treated and untreated people to investigate the effects of gender on treatment. However, this wealth of information remains largely untapped for such data reuse, partially because many biologists lack the computer programming expertise needed for data retrieval, processing and analysis. In addition, public database entries typically contain raw study data, which need to be structured for analysis. OMiCC aims to use crowdsourcing techniques to harness the expertise of the research community to overcome these challenges. Within the platform, users can create groups of gene expression data and "annotate" them by assigning parameters, such as sample type and disease, using a standardized vocabulary. OMiCC saves these user-created groups and associated annotations, making them available to others for reuse.
Within OMiCC, users can pool these groups of data and analyze information from multiple studies to search for biological relationships, a statistical approach known as meta-analysis. The NIAID scientists anticipate that as the OMiCC user community grows, the platform will develop into a rich resource that can transform the increasing amounts of public data into novel biological insights.
Behavior and Gene Expression In Young Stickleback Fish Influenced By The Dad
Stickleback fish fathers can cause their offspring to behave in a way that makes them less susceptible to predators.
Stickleback fish fathers can cause their offspring to behave in a way that makes them less susceptible to predators.
Gene Expression Patterns in Pancreatic Tumor Cells Identified in MGH Study
New research reveals that analysis of circulating tumor cells in a mouse model of pancreatic cancer identified distinct patterns of gene expression.
New research reveals that analysis of circulating tumor cells in a mouse model of pancreatic cancer identified distinct patterns of gene expression.
Research Sheds Light on Most Accurate Measures of Gene Expression
Research has indicated that RNA-sequencing allows measuring the gene expression of humans or other organisms.
Research has indicated that RNA-sequencing allows measuring the gene expression of humans or other organisms.
