COVID-19 Test: Oropharyngeal Secretions Offer More Accurate Results

Testing of oropharyngeal secretions (OS) help to limit the false negatives from nasal swab tests in patients who seem to have recovered from COVID-19 infection. The new study states that sampling of OS helps to improve detection of SARS-COV-2 by nuclei acid amplification. The findings are published in the Journal of Dental Research.

In the study, led by Jingzhi Ma, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Department of Stomatology, Wuhan, China, a small number of patients that had tested negative through nasopharyngeal swabs were found to be positive through the testing of oropharyngeal secretions.

Coronavirus
Coronaviruses infect animals, humans, and birds. Human coronaviruses, such as SARS, MERS, and 2019-nCoV cause respiratory distress and even death. The S protein is the infectious agent of the virus.

‘Nasal swab test has a risk providing false negative results to more patients who still have COVID-19 infection, while the oropharyngeal secretions (OS) test will make such errors in fewer patients.’
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The first prospective study of its kind included 75 ready-for-discharge COVID-19 patients who tested negative using two consecutive nucleic acid amplification testing (NAAT) of viral samples retrieved with nasopharyngeal swabs (NPS).

Because of detection of potential false-negatives in that cohort, NAAT results of paired OS and NPS samples collected from 50 additional COVID-19 recruits during their recovery stage were used in a second prospective study to compare the diagnostic values of the two viral RNA sampling methods.

Oropharyngeal secretions obtained from 2 of the 75 subjects in the first study yielded positive results for SARS-CoV-2 nucleic acid. In the second study, OS samples were significantly more sensitive for detection of the virus that NPS samples and missed only 14% of positive cases compared with 59% for the NPS samples.

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Sampling of OS is a simple procedure that can be performed in any quarantine setting and minimizes contact between healthcare workers and patients, thereby reducing the risk of virus transmission.

"The NPS test has a risk of sending home more patients who still have the infection while the OS test will make such errors in fewer patients. Although OS sampling improves the accuracy of SARS-CoV-2 nucleic acid testing, it must be emphasized that this conclusion is based on a very small sample size," stated Ma.

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Source-Eurekalert

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