Compound Prevents People from Going Deaf from Blaring Earphones

by Savitha C Muppala on  August 31, 2013 at 9:07 PM Research News   - G J E 4
Scientists have discovered a compound that could help keep the ear safe from noise-related damage.
 Compound Prevents People from Going Deaf from Blaring Earphones
Compound Prevents People from Going Deaf from Blaring Earphones

Xiaorui Shi, M.D., Ph.D., study author from the Department of Otolaryngology/Head and Neck Surgery at the Oregon Hearing Research Center at Oregon Health and Science University in Portland, Oregon, said that noise-induced hearing loss, with accompanying tinnitus and sound hypersensitivity is a common condition which leads to communication problems and social isolation.

Shi and colleagues used three groups of 6 - 8 week old mice, which consisted of a control group, a group exposed to broadband noise at 120 decibels for three hours a day for two days, and a third group given single-dose injections of pigment epithelium-derived factor (PEDF) prior to noise exposure.

PEDF is a protein found in vertebrates that is currently being researched for the treatment of diseases like heart disease and cancer.

The cells that secrete PEDF in control animals showed a characteristic branched morphology, with the cells arranging in a self-avoidance pattern which provided good coverage of the capillary wall.

The morphology of the same cells in the animals exposed to wide-band noise, however, showed clear differences-noise exposure caused changes in melanocytes located in the inner ear.

The new research has been published in Federation of the American Societies for Experimental Biology (FASEB) Journal.

Source: ANI

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