Mesenchymal stem cells (MSCs) are capable of multipotent differentiation, allowing them to contribute to bone regeneration and repair.
A new study of bone formation from stem cells seeded on 3D-printed
bioactive scaffolds combined with different mineral additives showed
that some of the scaffold mineral composites induced bone-forming
activity better than others.
‘Some of the 3D-printed bioactive scaffold combined with mineral composites induced bone-forming activity better than others, suggested a new study.’
The properties and potential to use these
bioactive scaffolds in bone regeneration applications are discussed in
an article published in Tissue Engineering, Part A
peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
Ethan Nyberg, Alexandra Rindone, Amir Dorafshar, and Warren
Grayson, Johns Hopkins University School of Medicine and Johns Hopkins
University, Baltimore, examined the print quality of several
different composite 3D-printed bone scaffolds.
In the article entitled
"Comparison of 3D-Printed Poly-ε-caprolactone Scaffolds Functionalized
with Tricalcium Phosphate, Hydroxyapatite, Bio-Oss, or Decellularized
Bone Matrix," they report on the mechanical and structural properties of
the various porous scaffolds, to which they added adipose-derived stem
cells. The researchers then assessed the bone-inducing properties of
each hybrid scaffold, measuring osteoblast formation, calcium content,
and collagen expression.
"In the continuum of materials used to regenerate bone,
harnessing the power of both biomaterial scaffolds and known crystalline
bone regeneration materials provides maximal flexibility in therapy,"
says Tissue Engineering Co-Editor-in-Chief Peter C. Johnson, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC,