X

Chronic Inflammation in Brain may be Precursor to Alzheimer’s Disease

by Kathy Jones on  July 02, 2012 at 11:18 PM Research News   - G J E 4
A -A +
Chronic inflammation may push the brain towards development of Alzheimer's disease, a new study published in the Journal of Neuroinflammation reveals.
 Chronic Inflammation in Brain may be Precursor to Alzheimer’s Disease
Chronic Inflammation in Brain may be Precursor to Alzheimer’s Disease

To date it has been difficult to pin down the role of inflammation in Alzheimer's disease (AD), especially because trials of NSAIDs appeared to have conflicting results. Although the ADAPT (The Alzheimer`s Disease Anti-inflammatory Prevention Trial) trial was stopped early, recent results suggest that NSAIDs can help people with early stages of AD but that prolonged treatment is necessary to see benefit.

Researchers from the University of Zurich, in collaboration with colleagues from the ETH Zurich and University of Bern investigated what impact immune system challenges (similar to having a severe viral infection) would have on the development of AD in mice. Results showed that a single infection before birth (during late gestation) was enough to induce long-term neurological changes and significant memory problems at old age.

These mice had a persistent increase in inflammatory cytokines, increased levels of amyloid precursor protein (APP), and altered cellular localization of Tau. If this immune system challenge was repeated during adulthood the effect was strongly exacerbated, resulting in changes similar to those seen for pathological aging.

Dr Irene Knuesel who led this research explained, "The AD-like changes within the brain of these mice occurred without an increase in amyloid β (Aβ). However, in mice genetically modified to produce the human version of Aβ, the viral-like challenge drastically increased the amount of Aβ at precisely the sites of inflammation-induced APP deposits. Based on the similarity between these APP/A aggregates in mice and those found in human AD, it seems likely that chronic inflammation due to infection could be an early event in the development of AD.



Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

Most Popular News on Medindia

P
M
X

Ask an Expert

Ask an Expert+
s
Responses to Chronic Pain Probed
 Responses to Chronic Pain Probed
S  Big Problem in '3rd-Gen' Genome Sequencing Overcome by Error-Eliminating Fix
Big Problem in '3rd-Gen' Genome Sequencing Overco...