Medindia

X

Chemotherapy Boosts Cancer Growth

by Sheela Philomena on  August 6, 2012 at 11:13 AM Cancer News   - G J E 4
Chemotherapy increases the growth of cancer cells, reveals study.

Researchers in the United States made the "completely unexpected" finding while seeking to explain why cancer cells are so resilient inside the human body when they are easy to kill in the lab.
 Chemotherapy Boosts Cancer Growth
Chemotherapy Boosts Cancer Growth
Advertisement

They tested the effects of a type of chemotherapy on tissue collected from men with prostate cancer, and found "evidence of DNA damage" in healthy cells after treatment, the scientists wrote in Nature Medicine.

Advertisement
Chemotherapy works by inhibiting reproduction of fast-dividing cells such as those found in tumours.

The scientists found that healthy cells damaged by chemotherapy secreted more of a protein called WNT16B which boosts cancer cell survival.

"The increase in WNT16B was completely unexpected," study co-author Peter Nelson of the Fred Hutchinson Cancer Research Center in Seattle told AFP.

The protein was taken up by tumour cells neighbouring the damaged cells.

"WNT16B, when secreted, would interact with nearby tumour cells and cause them to grow, invade, and importantly, resist subsequent therapy," said Nelson.

In cancer treatment, tumours often respond well initially, followed by rapid regrowth and then resistance to further chemotherapy.

Rates of tumour cell reproduction have been shown to accelerate between treatments.

"Our results indicate that damage responses in benign cells... may directly contribute to enhanced tumour growth kinetics," wrote the team.

The researchers said they confirmed their findings with breast and ovarian cancer tumours.

The result paves the way for research into new, improved treatment, said Nelson.

"For example, an antibody to WNT16B, given with chemotherapy, may improve responses (kill more tumour cells)," he said in an email exchange.

"Alternatively, it may be possible to use smaller, less toxic doses of therapy."

Source: AFP
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions
The researchers are missing the boat altogether.They are witnessing a natural phenomena I've explained 25 yrs ago in Cell Death Signal Theory as reviewed by M.D.Anderson Cancer Center [see cancerfraudbadbiotech for details ], but because they are treating cancer as a disease and not the aggravated medical condition it is (dna damaged embryogensis/apoptosis )they can't recognize the responses they are seeing.I used my ow theory and avoided chemo/radiation in 1997 and have been cancer free ever since .How sad people have to die such horrible deaths because the cancer industry is based on making money and not saving lives
eagreenhalgh Monday, August 6, 2012

You May Also Like

Advertisement
View All