Chemotherapy Better for Pancreatic Cancer Patients

by Dr. Enozia Vakil on  January 2, 2014 at 3:18 PM Cancer News   - G J E 4
An effective strategy has now been introduced to make chemotherapy better and more effective for pancreatic cancer patients.

The research found pancreatic cancer cells may have their own specialised energy supply that maintains calcium levels and keeps cancer cells alive.
 Chemotherapy Better for Pancreatic Cancer Patients
Chemotherapy Better for Pancreatic Cancer Patients

Maintaining a low concentration of calcium within cells is vital to their survival and this is achieved by calcium pumps on the plasma membrane.

This calcium pump, known as PMCA, is fuelled using ATP - the key energy currency for many cellular processes.

Scientists used cells taken from human tumours and looked at the effect of blocking each of these two energy sources in turn.

Their study showed that blocking mitochondrial metabolism had no effect. However, when they blocked glycolysis, they saw a reduced supply of ATP which inhibited the calcium pump, resulting in a toxic calcium overload and ultimately cell death.

The research has been published in The Journal of Biological Chemistry.

Source: ANI

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

View All