Central Nervous System Development and Disease Affected by The Olig Family

Research has shown that the oligodendrocyte transcription family (Olig family) is widely expressed in the central nervous system of various mammals. It plays a critical role in central nervous system development by controlling differentiation and maturation of oligodendrocytes, motor neurons and astrocytes. Moreover, accumulating evidence demonstrates Olig family participation in many central nervous system diseases.

Therefore, based on current literature, Dr. Lehua Yu and co-workers from Second Affliated Hospital, Chongqing Medical University in China examine the role of the Olig family in central nervous system development and related diseases. The Olig family is known not only to be an important factor in regulating neural cell differentiation, but also affects acute and chronic central nervous system diseases, including brain injury, multiple sclerosis, and even gliomas. Improved understanding about the functions of the Olig family in central nervous system development and disease will greatly aid novel breakthroughs in central nervous system diseases. The relevant paper has been published in the Neural Regeneration Research (Vol. 9, No. 3, 2014).



Source-Eurekalert