Medindia

X

Cancer Vaccines Spike Up the Immune System to Stop Tumour Progression

by Dr. Enozia Vakil on  July 14, 2013 at 11:20 PM Cancer News   - G J E 4
Cancer vaccines aim at reducing tumor progression by priming the immune system to attack cancer cells.
 Cancer Vaccines Spike Up the Immune System to Stop Tumour Progression
Cancer Vaccines Spike Up the Immune System to Stop Tumour Progression
Advertisement

IL-12p70, a molecule produced by certain types of immune cells, has been shown to reduce tumor progression, but delivering it as part of a cancer vaccine has been limited because of its toxicity in high doses.

Advertisement
In the current issue of the Journal of Clinical Investigation, Dr. Beatriz Carreno and colleagues at Washington University report the results of a clinical trial that tested a vaccine to treat newly diagnosed advanced melanoma. A portion of each patient's own immune cells, known as dendritic cells, were modified to stimulate increased production of IL-12p70 by their immune system. This method avoided the toxicity seen with previous approaches.

Carreno and colleagues found that IL-12p70 enhanced the effectiveness of the vaccine. Six out of seven patients exhibited a vaccine-stimulated immune response and three patients exhibited clinically significant changes in the progression of their tumors.

These results underscore the role of IL-12p70 in the development of an anti-cancer immune response.This study was funded Barnes-Jewish Hospital Foundation, Siteman Cancer Frontier Fund, Washington University/JNJ Translational Medicine Awards, and the National Cancer Institute. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, etc.

Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All