Can Over-The-Counter(OTC) Medications Treat Alcohol Abuse in Bipolar Patients?

by Madhumathi Palaniappan on  March 23, 2017 at 9:22 AM Alcohol & Drug Abuse News
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Alcoholism refers to the excessive drinking of alcohol which may result in serious health problems. Scientists have long wondered if medications can treat alcohol abuse.
Can Over-The-Counter(OTC) Medications Treat Alcohol Abuse in Bipolar Patients?
Can Over-The-Counter(OTC) Medications Treat Alcohol Abuse in Bipolar Patients?

Ihsan Salloum, M.D., chief of the Division of Alcohol and Drug Abuse, University of Miami Miller School of Medicine, hopes to find an answer for the question in a clinical trial with E.Sherwood Brown, M.D., Ph.D., at UT Southwestern Medical Center in Dallas.

The research study aimed to determine if over-the-counter medications can treat alcoholism in diagnosed bipolar patients.

The $2.5 million, five-year trial is currently in year two and funded by the National Institute of Alcohol Abuse and Alcoholism (NIAAA) of the NIH. The study will gauge the effectiveness of citicoline and pregnenolone, over-the-counter medications used for improved brain function and mood control, as a treatment for alcohol abuse in people who also suffer from bipolar disorder. While research on the use of prescription medications for curbing alcohol abuse in people with bipolar disorder has had very limited success, smaller previous studies have shown these two OTC medications can be effective, leaving Salloum and Brown excited about their potential.

"This proof of concept study hopes to accomplish what we in the medical community have long hoped for -- a medication to reduce alcohol abuse," said Salloum. "In addition, because of their properties, the two drugs being studied could also improve patients' moods and emotional balance."

The trial targets diagnosed bipolar disorder patients because more than 60 percent of this population suffers from some sort of alcohol-use disorder. These patients are also at higher risk for suicide and co-morbidities, such as illnesses and accidents, often attributed to either their diagnosis and/or alcohol use.

Over the course of the 12-week study in Miami and Dallas, participants will be assigned citicoline, pregnenolone or a placebo and take the medication twice daily. They will also need to attend a weekly appointment at the University of Miami Health System or UT Southwestern Medical Center for feedback.

Through 2018, the University of Miami and UT Southwestern will track patient data. If one or both of the OTC medications are successful in treating alcoholism in bipolar patients, the study will continue through years four and five. If citicoline and/or pregnenolone are deemed effective at the end of the five-year trial, larger studies will be launched to evaluate their viability in people with alcohol-use disorders who do not suffer from mental health problems.



Source: Eurekalert

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