A new study has found that a person's response to caffeine could help predict how a person will respond to other stimulant drugs, such as amphetamine and cocaine. UVM Associate Professor of Psychiatry Stacey Sigmon, Ph.D., and Johns Hopkins University colleague Roland Griffiths, Ph.D., first employed a choice procedure to identify participants as caffeine "Choosers" and "Nonchoosers" for the study.
Choosers were those who chose caffeine over placebo in the majority (>/= 7) of 10 choice session and Nonchoosers chose placebo over caffeine in the majority of choice sessions. There were no significant differences regarding pre-study caffeine intake or other characteristics between the two groups.
During the second phase of the study, all participants received various doses of d-amphetamine and rated how much they liked or disliked each dose.
The researchers found that caffeine Choosers reported significantly more positive subjective effects and fewer negative/unpleasant effects of d-amphetamine compared to Nonchoosers, particularly at the highest doses.
On the other hand, caffeine Nonchoosers reporter fewer positive effects and more unpleasant effects of d-amphetamine compared to Choosers.
"People differ dramatically in how they respond to drugs," says Sigmon.
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The study has been published in the journal Drug and Alcohol Dependence.
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