Breast Cancer Researchers Uncover 'Fountain of Youth' in Mammary Glands of GM Mice

by Bidita Debnath on  April 10, 2015 at 12:23 AM Research News
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Recently, scientists stumbled upon the "fountain of youth" while conducting a research on breast cancer.
Breast Cancer Researchers Uncover 'Fountain of Youth' in Mammary Glands of GM Mice
Breast Cancer Researchers Uncover 'Fountain of Youth' in Mammary Glands of GM Mice

It was found in the mammary glands of genetically modified mice. A research team led by Dr. Rama Khokha has found that when two factors that control tissue development are removed, people could avoid the impact of aging.

Think of tissue as a building that was constantly under renovation. The contractors would be "metalloproteinases," which are constantly working to demolish and reconstruct the tissue.

The architects in this case, who are trying to reign in and direct the contractors, are known as "tissue inhibitors of metalloproteinases," or TIMPs. When the architect and the contractors don't communicate well, a building could fall down. In the case of tissue, the result could be cancer.

In the normal course of aging, your tissue losses its ability to develop and repair as fast as it did when you were young. That's because stem cells, which are abundant in your youth, decline with the passing of time.

The University of Toronto team found that with the TIMP1 and TIMP3 architects missing, the pool of stem cells expanded and remained functional throughout the lifetime of these mice.

The team also found that despite large number of stem cells, there was no increased risk of cancer.

Source: ANI

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