Highlights
- An impaired gut microbiota can alter the brain's signals for appetite and satiety, and can influence obesity.
- Deep transcranial magnetic stimulation (dTMS) is a technique that sends magnetic pulses to stimulate specific deep regions of the brain.
- dTMS increased quantities of several beneficial bacterial species with anti-inflammatory properties and facilitated weight loss.
Unlike deep brain stimulation, dTMS does not need an operation or implantation of electrodes. Instead, an electromagnetic coil is placed on the scalp and sends magnetic pulses to stimulate specific deep regions of the brain.
A Secret Cause of Obesity
An underlying cause of obesity may be an impaired gut microbiota composition, an imbalance in the complex mix of beneficial and harmful microorganisms that inhabit the digestive tract.
"We need new safe and effective therapies for obesity," said principal investigator Livio Luzi, M.D., professor and head of endocrinology at the IRCCS Policlinico San Donato and the University of Milan in Milan, Italy. "Despite numerous preventive and therapeutic interventions, none has stopped obesity from reaching epidemic proportions."
dTMS Alters Gut Microbiota
They randomly assigned the study subjects to two groups for five weeks to receive 15 sessions--three times per week--of either dTMS (to the insula and prefrontal cortex deep in the brain) or a sham stimulation as a control. Before and at the end of treatment, subjects provided stool samples for microbiota analysis.
The research team also measured blood levels of glucose (sugar), insulin, pituitary gland hormones and neurotransmitters such as norepinephrine. Pituitary hormones play a key role in regulating appetite, and recent research shows that norepinephrine and other neurotransmitters affect microbiota composition, Luzi said.
- After five weeks of treatment, subjects receiving dTMS lost more than 3 percent of their body weight and more than 4 percent of their fat--significantly more than controls.
- dTMS-treated subjects had greatly increased quantities of several beneficial bacterial species with anti-inflammatory properties, such as are found in healthy people.
- Changes in the abundance of other bacterial species correlated with improvement of metabolic and hormonal parameters, including glucose, insulin, several pituitary hormones and norepinephrine.
Reference
- Livio Luzi et al., Magnetic brain stimulation causes weight loss by making gut bacteria healthier, ENDO 2017: The Endocrine Society's 99th Annual Meeting & Expo.
Source-Medindia