Drugs widely used to cure lung diseases, like asthma and pneumonia, work
with the body clock, which makes them ineffective, found a new study.
The study, led by Professors David Ray and Andrew Loudon from the
University of Manchester,
has discovered that cells lining the
lung airways have their own body clock which is the time-keeper for
lung inflammation - both conditions cause lungs inflammation and more
severe swelling in the lungs happens as a result of the loss of the
body clock working in these cells.
Andrew Loudon said that they had found key molecule known as CXCL5 that
facilitates lung inflammation which is a main regulator of how immune
cells get into tissues.
The loss of CXCL5 completely blocks the time of day regulation of lung
inflammation which opens up new ways to cure lung diseases.
The researchers also uncovered how glucocorticoid hormones from the
adrenal gland are significant in curbing the level of inflammation in
the cells lining the airway and concluded that the rhythm of the
clock in the lining of the cells in the lungs is significant for
lung diseases like asthma and chronic obstructive lung diseases.
Researchers said that they have defined a major circadian control on lung inflammation which affects responses to bacterial infection or
pneumonia. They know that many pulmonary diseases indeed show a
strong time of day effect, including asthma, and deaths from
The study was published in Nature Medicine