Blood Test Predicts Relapse of Breast Cancer Before New Tumors Are Detectable

Breast cancer is diagnosed early in 95% of cases, but knowing whether or not treatment is able to remove all signs of cancer is key to preventing the tumors from returning and spreading elsewhere in the body. An experimental blood test may be able to predict whether a woman with breast cancer will suffer a relapse months before new tumors would be detectable on scans, revealed a new study. The technology works by detecting cancer DNA that circulates in the bloodstream. While the test is not yet available to the public, and likely will not be for years to come, the research team is hopeful that it could help refine personalized treatments for cancer and perhaps lead researchers further down the path of finding a cure one day. Study author Nicholas Turner, team leader in molecular oncology at The Institute of Cancer Research, London, said, "We have shown how a simple blood test has the potential to accurately predict which patients will relapse from breast cancer, much earlier than we can currently. Ours in the first study to show that these blood tests could be used to predict relapse."

For the study, researchers took tumor and blood samples from 55 breast cancer patients with early-stage disease. Each of the patients had received chemotherapy and surgery to remove the tumor. The blood test was administered following cancer surgery and every six months afterward as a follow-up. Of the 15 women who saw their cancer return, this experimental test accurately predicted that relapse in 12 of them.

The test was also capable of detecting cancer an average of about eight months earlier than the tumors were visibly detectable on conventional scans. The study said, "The technique uses personalized digital polymerase chain reaction (dPCR) tests to track mutations and could be applied to all subtypes of breast cancer."

Turner said, "There are some technical challenges to implementing the technology, but digital PCR is relatively cost-effective and the information that it provides could make a real difference to breast cancer patients. It will be some years before the test could potentially be available in hospitals, but we hope to bring this date closer by conducting much larger clinical trials starting next year."

The study is described in Science Translational Medicine.

Source-AFP