Medindia

X

Blood Protein Could Help Combat Cardiovascular Disease

by Sheela Philomena on  March 12, 2012 at 2:04 PM Heart Disease News   - G J E 4
Pregnane X receptor (PXR) protein found in blood helps protect the body from substances which cause heart disease, say researchers.
 Blood Protein Could Help Combat Cardiovascular Disease
Blood Protein Could Help Combat Cardiovascular Disease
Advertisement

The findings, published online in the journal Cardiovascular Research, have revealed the protein protein pregnane X receptor (PXR) can switch on different protective pathways in the blood vessels.

Advertisement
Co-author Dr David Bishop-Bailey, based at Queen Mary's William Harvey Research Institute, said they found the protein was able to sense a wide variety of drugs, foreign chemicals and food products in the blood and switch on specific pathways to deal with them.

"We've known for a long time that this protein has an important role sorting out waste products in the liver - now we believe it could have an important role in protecting the body against cardiovascular disease," he said.

Dr Karen Swales, based at the University of Surrey, said: "Heart and circulatory disease is the UK's biggest killer. Discovering that the protein pregnane X receptor (PXR) could protect blood vessels has major implications for the prevention of cardiovascular disease."

"We knew if PXR played similar protective roles in blood vessels to those in the liver, it could protect the vessels from damage caused by harmful substances in the blood."

The researchers used human tissue and blood vessel cells in culture and found PXR was present and active.

Dr Bishop-Bailey added: "We introduced specific PXR activating drugs and saw a co-ordinated increase in metabolising and anti-oxidant enzyme pathways.

"Since blood travels everywhere in the body, PXR has the potential to provide protection not just through its actions in the liver, but anywhere in the entire body. If we can work out how to manipulate PXR to turn on detoxification and antioxidant pathways in blood vessels, we may be a step closer to preventing our nation's biggest killer."

Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All