New approaches to treating persistent viral infections like HIV and hepatitis C were suggested by UCLA scientists who have found that blocking a protein critical to immune response temporarily actually helps the body clear itself of chronic infection.
The research team studied type-1 interferons (IFN-1), proteins released by cells in response to disease-causing organisms that enable cells to talk to each other and orchestrate an immune response against infection. Constant IFN-1 signaling is also a trademark of chronic viral infection and disease progression, particularly in HIV.
Advertisement"When cells confront viruses, they produce type-1 interferons, which trigger the immune system's protective defenses and sets off an alarm to notify surrounding cells," explained principal investigator David Brooks, assistant professor of microbiology, immunology and molecular genetics at UCLA's David Geffen School of Medicine and College of Letters and Sciences.
"Type-1 interferon is like the guy in the watch tower yelling, 'red alert,' when the marauders try to raid the castle," he explained.
Scientists have long viewed IDF-1 as beneficial, because it stimulates antiviral immunity and helps control acute infection. Blocking IDF-1 activity, they reasoned, would allow infection to run rampant through the immune system.
On the other hand, prolonged IFN-1 signaling is linked to many chronic immune problems. The research team wondered whether obstructing the signaling pathway would enable the immune system to recover enough to fight off chronic infection.
To test this theory, Brooks and his colleagues injected mice suffering from chronic viral infection with an antibody that temporarily blocked IFN-1 activity.
Much to their surprise, they discovered that giving the immune system a holiday from IFN-1 boosted the body's ability to fight the virus. Stunningly, the respite also reversed many of the immune problems that result from chronic infection, such as a rise in proteins that suppress immune response, continuous activation of the immune system and disruption of lymph tissue.
The findings fly in the face of past studies that suggest eliminating IFN-1 activity in mice leads to severe, life-long infection.
"What we saw was entirely illogical. We'd blocked something critical for infection control and expected the immune system to lose the fight against infection. Instead, the temporary break in IFN-1 signaling improved the immune system's ability to control infection," said Brooks.
Uncovering this mechanism could offer potential for new therapies to tackle viruses like HIV and hepatitis C, according to Brooks.
The team's next step will be to pinpoint how to sustain IFN-1's control of the virus while blocking the negative impact that chronic IFN-1 activity wreaks on the immune system.
The finding has been published in the journal Science.
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