As many as 600 people in the Black Country and Staffordshire are dying early of heart attack each year because of poor health.
Increased intake of food high in fat and unhealthy lifestyle are the major cause of coronary heart disease, says the British Heart Foundation.
The Black Country records the highest death rates due to heart attack amongst people aged 75 and below.
Sandwell registered the highest rate with an average of 139 premature heart deaths, followed by Walsall with 126, Dudley with 123, and Wolverhampton with 106.
In Staffordshire, there were 41 early heart attack deaths in Cannock Chase, 39 in Stafford, 32 in South Staffordshire, and 42 in Lichfield.
Nearly 2,100 people prematurely die due to heart attack each year in the West Midlands. The British Heart Foundation estimates that more than 22,000 people under the age of 75 suffering a fatal attack.
Professor Peter Weissberg, medical director at the British Heart Foundation, said, "Through medical research, we have made great progress in saving the lives of people suffering from heart attacks. But we must not be lulled into thinking we have beaten the disease. Every year thousands of people are still dying from heart attacks, and coronary heart disease remains the UK's single biggest killer."
"We urgently need to fund more research to find new ways to prevent and treat heart attacks, and ultimately, save more lives. Despite knowing some of the lifestyle and genetic factors that increase the risk of heart attack, we still have no way to stop the furring of the arteries in coronary heart disease that is responsible for causing so many heart attacks. This is a challenge that only research can provide the answer to," said Weissberg.
Simon Gillespie, chief executive of the British Heart Foundation, said, "Every week heart attacks devastate hundreds of families across the UK, by killing loved ones at an early age and leaving many others with debilitating heart conditions that make the rest of their life a daily struggle."
"The only way we can find new ways to prevent and treat heart attacks is by funding more research. Thanks to the generous donations of our supporters, much of the research we have funded over the last 50 years is today helping to save and improve lives. We now need the continued backing of our supporters and the general public if we're to make the advances that could save even more lives from heart disease," said Gillespie.
The data has been released as the charity launched a new campaign to highlight how heart conditions, including heart attack, suddenly devastate families across the country on a daily basis.
Heart attack claims life of someone every three minutes in the UK - with almost 188,000 heart attacks treated in UK hospitals in 2013/2014.
One third of heart attacks are fatal, despite improvements in treatment and diagnosis.
Around 200,000 people in the West Midlands are living with coronary heart disease and it remains the UK's single biggest killer.