Beta Cell Replication can be Promoted by Targeting a Cell Cycle Inhibitor

by Kathy Jones on  January 18, 2014 at 10:37 PM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

The loss of beta cell mass, which results in decreased insulin production, is one of the factors underlying the development of type 2 diabetes.
 Beta Cell Replication can be Promoted by Targeting a Cell Cycle Inhibitor
Beta Cell Replication can be Promoted by Targeting a Cell Cycle Inhibitor

Once lost, β cell mass cannot be restored. In contrast, infants with focal hyperinsulinism of infancy exhibit rapid expansion of the β cell mass due to a silencing of a region of chromosome 11 that includes the gene encoding the cell cycle inhibitor p57Kip2. In this issue of the Journal of Clinical Investigation, Klaus Kaestner and colleagues at the University of Pennsylvania demonstrate that silencing the gene encoding p57Kip2 in isolated adult human islets promotes β cell replication and that these new cells exhibit many properties associated with β cells. This study provides an explanation for excessive β cell expansion in children with focal hyperinsulinism and suggests that targeting the p57Kip2 pathway in adults with type 2 diabetes may improve β cell function.



Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Parkinsons Disease Surgical Treatment 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive