Bacteria in Worm Gut may Aid or Kill Their Host Depending on Small Changes in DNA

by Kathy Jones on  July 9, 2012 at 6:44 PM Genetics & Stem Cells News   - G J E 4
A new study conducted by researchers at Michigan State University has found that a simple change in the DNA could turn the bacteria present in the guts of worms from being vital for their survival into deadly pathogens.
 Bacteria in Worm Gut may Aid or Kill Their Host Depending on Small Changes in DNA
Bacteria in Worm Gut may Aid or Kill Their Host Depending on Small Changes in DNA

Todd Ciche, assistant professor of microbiology and molecular genetics, has seen variants like this emerge sometimes by chance resulting in drastically different properties, such as being lethal to the host or existing in a state of mutual harmony.

Even though human guts are more complex and these interactions are harder to detect, the revelation certainly offers new insight that could lead to medical breakthroughs, he said.

"Animal guts are similar to ours, in that they are both teeming with microbes," said Ciche, who worked with researchers from Harvard Medical School.

"These bacteria and other microorganisms are different inside their hosts than isolated in a lab, and we're only beginning to learn how these alliances with microbes are established, how they function and how they evolve," he added.

The bacteria in question are bioluminescent insect pathogens. In their mutualistic state, they reside in the intestines of worms, growing slowly and performing other functions that aid nematode's survival, even contributing to reproduction.

As the nematodes grow, the bacteria reveal their dark side. They flip a DNA switch and arm themselves by growing rapidly and producing deadly toxins. When the worms begin infesting insects, they release their bacterial insecticide.

"It's like fleas teaming up with the plague," Ciche said.

But the question of what causes this dramatic transformation remains.

"If we can figure out why the DNA turns on and off to cause the switch between Jekyll and Hyde, we can better understand how bacteria enter stages of dormancy and antibiotic tolerance - processes critical to treating chronic infections," Ciche added.

The finding appears in the current issue of Science.

Source: ANI

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