Babies Born to Unhealthy Parents ‘Pre-Programmed’ With Greater Risk of Poor Health

Researchers at University of Adelaide have found that the future health of a newborn baby does not depend solely on the parents’ genes and those born to unhealthy parents are at a greater risk of suffering from poor health.

In a feature paper called "Parenting from before conception" published in today's issue of the top international journal Science, researchers at the University's Robinson Research Institute say environmental factors prior to conception have more influence on the child's future than previously thought.

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"This really is a new frontier for reproductive and developmental research," says corresponding author and Director of the University's Robinson Research Institute, Professor Sarah Robertson.

"It's only been in the last 10 years that the science community has been seriously discussing these issues, and only in the last five years that we've begun to understand the mechanisms of how this is happening – with much of the work conducted right here at the University of Adelaide."

The paper concludes that parental influences on a child begin before conception, because stored environmental factors in the egg and sperm are contributing more than just genetic material to the child.

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"Many things we do in the lead up to conceiving is having an impact on the future development of the child – from the age of the parents, to poor diet, obesity, smoking and many other factors, all of which influence environmental signals transmitted into the embryo," Professor Robertson says.

"People used to think that it didn't matter, because a child represented a new beginning, with a fresh start. The reality is, we can now say with great certainty that the child doesn't quite start from scratch – they already carry over a legacy of factors from their parents' experiences that can shape development in the fetus and after birth. Depending on the situation, we can give our children a burden before they've even started life."

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This includes a higher risk of metabolic diseases, such as diabetes and cardiovascular disease. The likelihood of conditions like anxiety and immune dysfunction can also be affected.

Professor Robertson says current research is also showing that the fathers have a much greater role to play in this than previously thought.

Professor Robertson says this news is not all doom and gloom for would-be parents. "A few lifestyle changes by potential parents and improvements in the right direction, especially in the months leading up to conception, could have a lasting, positive benefit for the future of their child," she says.

Source-Eurekalert