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Autologous Hematopoietic Cell Transplant (HCT) Sends Multiple Sclerosis into Remission

by Dr. Trupti Shirole on  December 30, 2014 at 11:36 PM Genetics & Stem Cells News   - G J E 4
A new study published in the JAMA has revealed that for patients with relapsing-remitting multiple sclerosis (RRMS), high-dose immunosuppressive therapy (HDIT) with autologous hematopoietic cell transplant (HCT) is related with sustained remission and improvements in neurologic function.
 Autologous Hematopoietic Cell Transplant (HCT) Sends Multiple Sclerosis into Remission
Autologous Hematopoietic Cell Transplant (HCT) Sends Multiple Sclerosis into Remission
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Most patients with RRMS who received disease-modifying therapies experience breakthrough disease. Autologous (i.e. using a patient's own cells) HCT has been studied in RRMS with the goal of removing disease-causing immune cells and resetting the immune system.

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Researchers examined the effectiveness of early intervention with HDIT/HCT for patients with RRMS and breakthrough disease. They found that of the 24 patients who received HDIT/HCT, the overall rate of event-free survival was 78.4 percent at 3-years, which was defined as survival without death or disease from a loss of neurologic function, clinical relapse or new lesions observed on imaging, while progression-free survival and clinical relapse-free survival were 90.9 percent and 86.3 percent, respectively, at 3-years. The adverse events were consistent with the expected toxic effect of HDIT/HCT and no acute treatment-related neurologic adverse events were seen. Researchers also noted improvements in neurologic disability, quality-of-life and functional scores.

The study is titled 'The Hematopoietic Cell Transplantation for Relapsing-Remitting Multiple Sclerosis (HALT-MS)'.

Source: Medindia
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