Aspartic Acid: A Biomarker for Postoperative Cognitive Dysfunction

by Bidita Debnath on  March 30, 2014 at 12:10 AM Research News
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Postoperative cognitive dysfunction is the deterioration of cognitive performance after anesthesia and surgery.

And it manifests as impairments in short-term memory, concentration, language comprehension and social integration skills.
 Aspartic Acid: A Biomarker for Postoperative Cognitive Dysfunction
Aspartic Acid: A Biomarker for Postoperative Cognitive Dysfunction

Previous studies have shown that the occurrence of postoperative cognitive dysfunction is affected by many factors, including advanced age, low educational level, pre-existing cognitive impairment, alcohol abuse, and severity of coexisting illness. However, the real cause for postoperative cognitive dysfunction is still unclear.

Metabolite changes have been reported in various neurodegenerative diseases, but not in postoperative cognitive dysfunction. A research team from Third Xiangya Hospital, Central South University in China performed correlation analysis between changes in hippocampal metabolites and cognitive dysfunction in aged rats, and suggested aspartic acid concentration in the hippocampus may be a biomarker for predicting the occurrence and disease progress of cognitive dysfunction. The relevant paper has been published in the Neural Regeneration Research (Vol. 9, No. 2, 2014).

Source: Eurekalert

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