Medindia

X

Antidepressants Effective in Alleviating Osteoarthritis Pain

by VR Sreeraman on  March 23, 2012 at 5:13 PM Drug News   - G J E 4
A new study has found that antidepressants could be an effective option in easing painful conditions like osteoarthritis with fewer side-effects than the traditionally prescribed drugs like anti-inflammatories and opioids.
 Antidepressants Effective in Alleviating Osteoarthritis Pain
Antidepressants Effective in Alleviating Osteoarthritis Pain
Advertisement

Leslie Citrome, professor of psychiatry and behavioural sciences and Amy Weiss-Citrome from New York Medical College, analysed the latest clinical evidence on duloxetine, an antidepressant approved by the FDA for use in chronic musculoskeletal pain, including osteoarthritis.

Advertisement
"It is not uncommon to treat osteoarthritis with a combination of drugs that work in different ways," explained Citrome, the International Journal of Clinical Practice reported.

"Our review supports this approach and confirms that antidepressants are not just for depression and can play a key role in relieving this painful condition," Citrome adds, according to a university statement.

The authors looked at studies exploring the effects of duloxetine being used on its own or in combination with non-steroidal anti-inflammatory drugs (NSAIDs).

NSAIDs are used to treat inflammation, mild to moderate pain, and fever. Specific uses include the treatment of headaches, arthritis, sports injuries, and menstrual cramps.

These included the two randomised double-blind, placebo controlled clinical trials that formed the basis of FDA approval for duloxetine for the treatment of chronic pain linked with osteoarthritis.

When the side-effects of the various drugs were taken into account, this showed that when duloxetine was used on its own for 13 weeks it provided a number of advantages over NSAIDs, which can lead to gastrointestinal bleeding, and opiates (pain killers) such as morphine, which can cause constipation.

The most common side effects of duloxetine - nausea, fatigue and constipation - were small when compared to the placebo. The studies used to gain FDA approval also showed that pain reduction using duloxetine on its own was not dependent on an improvement in depressive symptoms.

Source: IANS
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All