Anti-cancer Drug Causes Bone Loss

by Sheela Philomena on  February 7, 2012 at 8:39 AM Drug News   - G J E 4
A drug commonly used to prevent breast cancer in post-menopausal women weakens bone density thus increasing fracture risk, reveals study.
 Anti-cancer Drug Causes Bone Loss
Anti-cancer Drug Causes Bone Loss

Exemestane -- brand name Aromasin -- is part of a drug class called aromatase inhibitors, which lower levels of the oestrogen that some breast cancers need in order to grow.

Canadian bone specialists took a look at a group of patients who had taken part in a study into the effectiveness of exemestane among 4,500 healthy women with a worrying family history of breast cancer.

Overall, the big study showed that the drug was highly effective, reducing the risk of breast cancer by almost two-thirds.

The bone sub-study looked at 351 women who had been taking either exemestane or a dummy lookalike pill and whose bone density was measured with hi-tech scanners.

After two years, women taking exemestane had a high loss of bone density at a common fracture point in the wrist called the distal radius, and also at the lower end of the tibia, compared with their counterparts on placebo.

The exemestane users also had an eight-percent decline in the thickness of cortical bone, which comprises the protective outer shell of the bones.

That finding in particular is worrying because nearly four out of every five fractures in old age occur in cortical bone. These accidents are a huge source of disability.

"Women considering exemestane for the primary prevention of breast cancer should weigh their individual risks and benefits," says the study, headed by Angela Cheung of the University Health Network in Toronto.

"For women taking exemestane, regular bone monitoring plus adequate calcium and vitamin D supplementation are important."

The paper is published online by the journal The Lancet Oncology.

Source: AFP

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

View All