Angiogenesis And Cancer Growth Controllable By Methylation Signaling

by Dr. Enozia Vakil on  November 29, 2013 at 4:02 PM Cancer News
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A new mechanism that involves a signalling protein and its receptor could now block the spread of cancer and formation of new blood vessels, according to a new study. The findings are published in the December issue of Science Signaling.
 Angiogenesis And Cancer Growth Controllable By Methylation Signaling
Angiogenesis And Cancer Growth Controllable By Methylation Signaling

Angiogenesis creates new blood vessels in a process that can lead to the onset and progression of several diseases such as cancer and age-related macular degeneration.

Vascular endothelial growth factor (VEGF) is a signaling protein produced by damaged cells, which binds to one of its receptors VEGFR-2, located on the surface of blood vessel cells. Once VEGF is bound to its receptor, it is activated and sends a biochemical signal to the inside of the blood vessel cell to initiate angiogenesis. There are currently multiple Federal Drug Administration-approved medications that target this process. However these medications are limited by insufficient efficacy and the development of resistance.

The researchers demonstrated that a biochemical process called methylation, which can regulate gene expression, also affects VEGFR-2, and this can lead to angiogenesis. Using multiple methods, the researchers were able to interfere with the methylation process of VEGFR-2 and subsequently block angiogenesis and tumor growth.

"The study points to the methylation of VEGFR-2 as an exciting, yet unexplored drug target for cancer and ocular angiogenesis, ushering in a new paradigm in anti-angiogenesis therapy," said Nader Rahimi, PhD, associate professor of pathology, BUSM, who served as the study's senior investigator.



Source: Eurekalert

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