Age-Related Macular Degeneration Caused by Impaired Autophagy

by Kathy Jones on  August 23, 2013 at 7:26 PM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

Impaired function of autophagy, or the lysosomal clean-up mechanism, in the fundus of the eye is responsible for the degenerative changes and loss of vision in age-related macular degeneration (AMD), according to a new study published in the journal PLoS One.
 Age-Related Macular Degeneration Caused by Impaired Autophagy
Age-Related Macular Degeneration Caused by Impaired Autophagy

The results open new avenues for the treatment of the dry form of AMD, which currently lacks an efficient treatment. The University of Eastern Finland played a leading role in the study, which also involved research groups from Italy, Germany and Hungary.

AMD is the most common cause of visual impairment in the Western world, and the number of AMD patients is expected to soar in the upcoming decades. AMD is divided into the dry and wet form of the disease, and 85% of AMD patients suffer from dry AMD. Unfortunately, an efficient treatment involving injections into the eye only exists for the wet form of the disease.

AMD is a storage disease in which harmful protein accumulations develop behind the retina. These accumulations are indicative of the severity of the disease. As the disease progresses, retinal sensory cells in the central vision area are damaged, leading to loss of central vision. The cell biological mechanisms underlying protein accumulations remain largely unknown.

For the first time ever, the present study showed that AMD is associated with impaired lysosomal autophagy, which is an important clean-up mechanism of the fundus of the eye. This renders the cells in the fundus of the eye unable to dispose of old, deformed or otherwise faulty proteins, which, in turn, leads to the development of protein accumulations and loss of vision. The study can be regarded as a breakthrough, as the results change our understanding of the pathogenesis of AMD and also open new avenues for the treatment of the dry form of AMD. Drugs inhibiting the impairment of autophagy could possibly even stop the progression of AMD.



Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Parkinsons Disease Surgical Treatment Blindness Facts 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement
Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

Advertisement

News Category

News Archive