Activation of Signal-Regulated Kinase 1/2 Exhibits Protective Effect on Neuronal Injury

by Bidita Debnath on  July 11, 2014 at 12:26 AM Research News
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In acute cerebral ischemia, activation of extracellular signal-regulated kinase 1/2 has been demonstrated.
 Activation of Signal-Regulated Kinase 1/2 Exhibits Protective Effect on Neuronal Injury
Activation of Signal-Regulated Kinase 1/2 Exhibits Protective Effect on Neuronal Injury

Yaning Zhao and her colleagues, Hebei United University, China induced transient whole-brain ischemia by four-vessel occlusion in normal and diabetic rats and intravenously injected diabetic rats with extracellular signal-regulated kinase 1/2 30 minutes before ischemia as a pretreatment.

Results showed that during the pathological progression of cerebral ischemia/reperfusion in rats, activation of extracellular signal-regulated kinase 1/2 exhibits protective effect on neuronal injury.

Reduced extracellular signal-regulated kinase 1/2 decreases Ku70 activity, increases Bax expression and thereby increases the number of lost hippocampal neurons in diabetic rats after cerebral ischemia/reperfusion. These results were published in Neural Regeneration Research (Vol. 9, No. 7, 2014).

Source: Eurekalert

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