A-type Lamins Intervene When Chromatin is Targeted

by Julia Samuel on  January 8, 2015 at 4:22 PM Research News   - G J E 4
Regulation of gene activity is mainly concerned with nuclear organization.

The associations of the regulatory regions of the genome with the nuclear lamina have been identified.
A-type Lamins Intervene When Chromatin is Targeted
A-type Lamins Intervene When Chromatin is Targeted

Information about these lamina-associated domains (LADs) directed to the nuclear lamina is sparse.

Chromosomal insertion site system was used to identify small sequences from borders of fibroblast-specific variable LADs that are sufficient to target these ectopic sites to the nuclear periphery.

YY1 (Ying-Yang1) binding sites as enriched in relocating sequences were identified. There was no lamina association as lamina A was not knocked down like YY1 or lamin A/C.

In addition, targeted recruitment of YY1 proteins facilitated ectopic LAD formation dependent on histone H3 lysine 27 trimethylation and histone H3 lysine di- and trimethylation.

The results also reveal that endogenous loci appear to be dependent on lamin A/C, YY1, H3K27me3, and H3K9me2/3 for maintenance of lamina-proximal positioning.

Source: Medindia

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