A single allele of tumour suppressor genes is enough to put a person at risk of cancer, according to a new study.
In the study focussing on SMAD4, a tumour suppressor gene implicated in pancreatic and colorectal cancer, the researchers found that such genes don't really need both alleles to be knocked out before disease phenotypes are expressed.
They found that having one mutated SMAD4 allele was associated with the development of gastrointestinal polyps.
This is the first study to deal with the molecular and cellular consequences of SMAD4 damage on a genome-wide scale.
About Cancer in Women
Cancer is one of the frequently talked about and most feared disease that falls under the genre of lifestyle diseases that have evolved, rather rapidly, in the past two decades.
Cancer is one of the frequently talked about and most feared disease that falls under the genre of lifestyle diseases that have evolved, rather rapidly, in the past two decades.
Source-ANI
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Breast cancer is a cancer that affects the breasts or mammary glands. Early detection and lifestyle changes help in controlling breast cancer.
Breast cancer is a cancer that affects the breasts or mammary glands. Early detection and lifestyle changes help in controlling breast cancer.
Pancreatic Cancer - All About the Disease, its Diagnosis and Management
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
