In Virus-induced Type 1 Diabetes in Rats, Haptoglobin is an Early Serum Biomarker
It is well-known that type 1 diabetes (T1D), formerly known as juvenile diabetes, is a multifactorial disease of complex etiology
It is well-known that type 1 diabetes (T1D), formerly known as juvenile diabetes, is a multifactorial disease of complex etiology
‘Haptoglandin, a glycoprotein in human blood, has many biochemical and metabolic roles such as hosting defense responses to infection and inflammation, acting as an antioxidant, antibacterial and anti-inflammatory roles. A new highly sensitive and disposable biosensing tool has been fabricated for the determination of Haptoglobin in blood.’
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In this research, a highly sensitive and disposable Indium Tin Oxide (ITO) based biosensing tool was developed. Featuring the considerable superiorities of ITO substrates, suitability for disposable biosensors, low cost, and repeatability, a novel anti-Hp based biosensor was created with a very low detection limit.
Anti-Hp antibody was utilized in this research for fabrication of such a disposable biosensor integrated with ITO substrates for the first time. The new biosensor presents highly analytical performance with a linear range 0.2 fg/mL - 1fg/mL. Kramers-Kronig Transform was performed on the experimental impedance data. The single frequency impedance technique was first used for characterization of interaction between Haptoglobin and anti-Haptoglobin.
Our research suggests that ITO substrates can be used in other biosensing strategies with high reproducibility and repeatability. Besides, the single frequency impedance technique can be performed in the evaluation of association and dissociation relations of bimolecular interactions, successfully.
Biosensing To Be Improved By Bacteria-Filled Liquid Crystals
A new physics takes over when you plop living, swimming bacteria in a water-based, non-toxic liquid crystal
A new physics takes over when you plop living, swimming bacteria in a water-based, non-toxic liquid crystal
Combining Plasma Screening Methods Identifies Diagnostic and Therapeutic Targets
A team of German researchers has managed to combine genomic and proteomic analysis of blood plasma that could help improve the identification of genetically regulated protein traits.
A team of German researchers has managed to combine genomic and proteomic analysis of blood plasma that could help improve the identification of genetically regulated protein traits.
Molecular Switch in Plasma Cells That Creates Long-Term Immunity Found
The protein is essential for antibody-producing plasma cells to migrate into bone marrow, preserving them for many years or even decades.
The protein is essential for antibody-producing plasma cells to migrate into bone marrow, preserving them for many years or even decades.
