For men who hate wearing a condom during sex, a new
non-intrusive solution is on the anvil - a birth control pill. At least two
projects are in the pipeline for choking male fertility.
One is H2-gamendazole that makes sperms go half-cooked.
Normally, premature sperm cells grow a tail and head in the testis, but
H2-gamendazole keeps them from reaching this stage of development.
Joseph Tash, a reproductive biologist at the University of
Kansas' Medical Centre in the US, said, "If there's no sperm, the egg's not
going to get fertilised."
The biologist has worked on the compound since 2001. The
other potential compound is JQ1 that can trick the body into forgetting how to
make sperm! JQ1 was found blocking bromodomain proteins in cancer cells by Jay
Bradner and his team at Harvard's Dana-Farber Cancer Institute.
The uncontrolled division of the abnormal cells ceased due
to it. JQ1 also obstructed a testicle-specific bromodomain called BRDT, making
the sex cells that would otherwise produce sperms draw a blank about their own
Mice treated with JQ1 can copulate with abandon yet produce
zero offsprings. But it will be several years before the drug is available.
Researchers would have to find a version of the molecule that works on the
testicle protein without coming up with any side effects.