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World First: Japanese Scientists Create Transgenic Monkeys
The exploit opens up exciting prospects for medical researchers, they said.
It could eventually lead to lab monkeys that replicate some of humanity's most devastating diseases, providing a new model for exploring how these disorders are caused and how they may be cured.
"Great advances in pre-clinical research can be expected using these models," the team said.
But other voices warned of a potential ethics storm, brewed by fears that technology used on our closest animal relatives could be turned to create genetically-engineered humans.
In a study published in the British journal Nature, a team led by Erika Sasaki of the Central Institute for Experimental Animals at Keio University reported on experiments on common marmosets (Callithrix jacchus), a small monkey native to Brazil.
They introduced a foreign gene, tucked inside a virus, into marmoset embryos that were then nurtured in a bath of sucrose.
The gene codes for green fluorescent protein (GFP), a substance that was originally isolated from a jellyfish and is now commonly used as a biotech marker. An animal tagged with GFP glows green when exposed to ultraviolet light, proving that a key gene sequence has been switched on.
The transgenic embryos were then implanted in the uterus of seven surrogate mother marmosets.
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