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Women Undergoing Estrogen Therapy at Risk of Developing Benign Breast Disease

by Medindia Content Team on  April 10, 2008 at 12:28 PM Women Health News   - G J E 4
Postmenopausal women undergoing a common estrogen replacement regimen have more than twice the risk of developing benign breast disease than women receiving no treatment, according to a new study.
Women Undergoing Estrogen Therapy at Risk of Developing Benign Breast Disease
Women Undergoing Estrogen Therapy at Risk of Developing Benign Breast Disease
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The study, first posted Tuesday in the online edition of The Journal of the National Cancer Institute, tracked some 10,739 postmenopausal women.

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Some of the subjects in the study were given conjugated equine estrogen, a commonly-prescribed form of estrogen, while others received a placebo.

After a median follow-up of seven years, the researchers found a total of 232 cases of benign proliferative breast disease -- 155 among the women who took estrogen supplements, and about half as many, 77, in the placebo group.

The study noted that while not a harmful condition, benign proliferative breast disease often is a precursor to malignant breast cancer.

"Although the women taking conjugated equine estrogen have not yet shown a significant increased risk of breast cancer ... they might show increased risk later," the authors concluded.

"Ongoing follow-up of the study participants may help to resolve this issue," they wrote.

Source: AFP
SRM/L
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