Wiener Dog's Stubby Legs may Hold Clue to Human Dwarfism

by Sreeraman on  July 27, 2009 at 4:24 PM Research News
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Parker said that other species, including humans, probably also carry single mutations that have big physical consequences.

In fact, humans have their own version of the gene that Parker connected to short legs in dogs: fibroblast growth factor 4 (fgf4).

Fgf4 hasn't been linked to short limbs in humans, at least not yet.

About two-thirds of cases of Hypochondroplasia, a type of human dwarfism, are instead related to a different gene: fgf3.

But "at least a third of the cases have no known genetic cause," Parker said. "Perhaps, the new dog-related fgf4 findings could give researchers a new route to look for," she added.

Source-ANI
SRM
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