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Why Women Are 10 Times More Susceptible To Lupus Than Men?
Researchers at UT Southwestern Medical Center identified the gene called IRAK1 as part of an international human genetic study.
Systemic lupus erythematosus, or lupus for short, causes a wide range of symptoms such as rashes, fever or fatigue that make it difficult to diagnose.
Dr. Chandra Mohan, professor of internal medicine and senior author of the study, said that identifying IRAK1 as a disease gene may also have therapeutic implications.
"Our work also shows that blocking IRAK1 action shuts down lupus in an animal model. Though many genes may be involved in lupus, we only have very limited information on them," he said.
He also said that locating IRAK1 on the X chromosome also represents a breakthrough in explaining why lupus seems to be sex-linked.
He pointed out that researchers have for long focused on hormonal differences between males and females as a cause of the gender difference.
"This first demonstration of an X chromosome gene as a disease susceptibility factor in human lupus raises the possibility that the gender difference in rates may in part be attributed to sex chromosome genes," he said.
The study involved 759 people who had developed lupus in their childhood, 5,337 patients who had developed it as adults, and 5,317 healthy controls.
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