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Why Sleep Deprivation Affects Some People More Than Others
Researchers observed that people who are genetically vulnerable to sleep loss showed reduced brain activity after staying awake all night, while those who are genetically resilient showed expanded brain activity.
The findings help explain individual differences in the ability to compensate for lack of sleep.
"The extent to which individuals are affected by sleep deprivation varies, with some crashing out and others holding up well after a night without sleep," said Dr. Michael Chee, at the Duke-National University of Singapore Graduate Medical School.
In the current study, the researchers, led by Dr. Pierre Maquet, at the University of Liege in Belgium selected study participants based on their genes.
Previous research showed that the PERIOD3 (PER3) gene predicts how people will respond to sleep deprivation. People carry either long or short variants of the gene.
Those with the short PER3 variant are resilient to sleep loss - they perform well on cognitive tasks after sleep deprivation.
However, those with the long PER3 variant are vulnerable - they show deficits in cognitive performance after sleep deprivation. Now the new study explains why.
The authors imaged study participants while they did a working memory task that requires attention and cognitive control - also called executive function.
They found that the resilient, short gene variant group compensated for sleep loss by "recruiting" extra brain structures.
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More News on: Sleep Problems in Children, Sleep Disorder : Restless Legs Syndrome, Sleep Disorder: Sleepwalking, Periodic Limb Movement Disorder, Circadian Rhythm and Sleep Disorders, REM Behavior Disorder, Sleep Disturbances In Women, Sleep, Insomnia, Obstructive Sleep Apnea
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