A discovery that may lead to the single most important medical breakthrough in human history-significantly longer lifespans has been announced by an Indian-origin researcher in Texas.
Writing about the finding in The FASEB Journal, VA Medical Center's Professor Asish Chaudhuri says that proper protein folding over time in long-lived bats explains why they live significantly longer than other mammals of comparable size, such as mice.
"Ultimately we are trying to discover what underlying mechanisms allow for some animal species to live a very long time with the hope that we might be able to develop therapies that allow people to age more slowly," said the senior researcher.
His team made this discovery by extracting proteins from the livers of two long-lived bat species-Tadarida brasiliensis and Myotis velifer-and young adult mice.
The researchers exposed the livers extracted to chemicals known to cause protein misfolding.
After examining the proteins, they found that the bat proteins exhibited less damage than those of the mice, indicating that bats have a mechanism for maintaining proper structure under extreme stress.
"Maybe Juan Ponce De Leon wasn't too far off the mark when he searched Florida for the Fountain of Youth," said Dr. Gerald Weissmann, Editor-in-Chief of The FASEB Journal.
"As it turns out, one of these bat species lives out its long life in Florida. Since bats are rodents with wings, this chemical clue as to why bats beat out mice in the aging game should point scientists to the source of this elusive fountain," Dr. Weissmann added.